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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 861887Generated: October 30, 2026

Diethyl [(2-aminophenyl)methyl]phosphonate → 7-cyclohexyl-N-(2-diethoxyphosphorylmethylphenyl)-3,4-dihydronaphthalene-2-carboxamide

https://huagongshe.com/reaction/861887

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl [(2-aminophenyl)methyl]phosphonateHCID 13649220—
Reactant7-Cyclohexyl-3,4-dihydronaphthalene-2-carboxamideHCID 19700497—
Product7-cyclohexyl-N-(2-diethoxyphosphorylmethylphenyl)-3,4-dihydronaphthalene-2-carboxamideHCID 1970051053%

Reaction Steps

7-Cyclohexyl-3,4-dihydronaphthalene-2-carboxamide and diethyl 2-aminobenzylphosphonate were reacted in the same manner as in Example 3 to yield 7-cyclohexyl-N-(2-diethoxyphosphorylmethylphenyl)-3,4-dihydronaphthalene-2-carboxamide (53%), which was then recrystallized from ethanol-water to yield colorless crystals having a melting point of 102°-103° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05716944
Source datasetuspto-grants-1998_02
ORD IDord-23b8ad1a1ff24e6682498cc920691fff
Source noteuspto-grants-1998_02