2,6-Lutidine → HCID 56987241, compound

Participants

Reaction Steps

A solution of thionyl chloride (530 μl, 7.27mmol) in THF (3 ml) was added to 4-methoxybenzyl (RS)-2-hydroxy-2-[(3S, 4R)-4-[3-oxo-3-[(S)-tetrahydrofuran-2-yl]propyl]-3-phthalimidoazetidin-2-on-1-yl]acetate (2.59 g, 4.84 mmol) and 2,6-lutidine (850 μl, 7.30 mmol) in THF (50 ml) at -20° C. After stirring for 1 h, the reaction mixture was filtered through a pad of celite, and the filtrate evaporated in vacuo. Toluene was added and re-evaporated to yield 4-methoxybenzyl (RS)-2-chloro-2-[(3S,4R)-4-[3-oxo-3-[(S)-tetrahydrofuran-2-yl]propyl]-3-phthalimidoazetidin-2-on-1-yl]acetate.

Provenance & Evidence