HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 861903Generated: October 30, 2026
1-Benzylpiperazine → 6-(4-Benzyl-1-piperazinyl)hexylsulfonic acid
https://huagongshe.com/reaction/861903
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | Sodium 6-bromohexanesulfonate | HCID 23667833 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(4-Benzyl-1-piperazinyl)hexylsulfonic acid | HCID 19700571 | 64.5% |
Reaction Steps
1-Benzylpiperazine (3.5 g), sodium 6-bromohexylsulfonate (16.2 g) and dry dimethylformamide (150 ml) are added to a flask and the mixture is heated and stirred at 180° C. for 16 hours. Precipitated crystals are collected by filtration and recrystallized from ethanol-diethyl ether to give 6-(4-benzyl-1-piperazinyl)hexylsulfonic acid (4.36 g, 63.5%) as colorless prisms. mp. 228°-230° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05716950 |
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| Source dataset | uspto-grants-1998_02 |
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| ORD ID | ord-d319ee040a9247468392bb047861fabc |
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| Source note | uspto-grants-1998_02 |
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