Potassium Hydroxide → HCID 70187003, compound

HRID 861905Notes

Reaction equation

HRID 861905 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH:15]3[CH2:20][NH:19][CH2:18][CH2:17][N:16]3[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][S:27]([NH2:30])(=[O:29])=[O:28])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[K:31].[OH-].[K+].CC(C)([O-])C.[K+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH:15]3[CH2:20][NH:19][CH2:18][CH2:17][N:16]3[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][S:27]([NH2:30])(=[O:29])=[O:28])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[K:31]

Participants

5

Reactant 4

HCID 14797Potassium HydroxideHCID 5462222PotassiumHCID 19700568HCID 19700568, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 70187003HCID 70187003, compound

Procedure

6-[[4-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]hexylsulfonamide prepared according to Method A is converted into potassium salt using aqueous potassium hydroxide solution or potassium tert-butoxide and recrystallized from methanol-diethyl ether to give the title compound as colorless crystals.

Workup

  1. customrecrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-41002b82ab4649398a63864727a49496
Source dataset
uspto-grants-1998_02
Patent number
US05716950

Reaction notes

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