Isoamylamine → HCID 21476259, compound

Participants

Reaction Steps

A solution of amino 3-methylbutane (1.5 g) in THF (20 ml) was dropped into a solution of 2-fluoronitrobenzene (2.4 g) in THF (20 ml), at 23° under a nitrogen atmosphere. The mixture was stirred at 23° for 3 h, then heated at reflux for 1.5 h. The mixture was allowed to cool to 23°, then concentrated under vacuum to give a crude compound which was purified by flash chromatography on silica gel using CH-EA 9/1 as eluants to give the title compound as a yellow oil (2.12 g). T.l.c. CH-EA (8/2), Rf 0.79. IR:3383 (NH); 1620 (C=C) cm-1.

Provenance & Evidence