Triethylamine → HCID 19700638, compound

Participants

Reaction Steps

1-Adamantanecarbonyl chloride (1.91 g )) was dropped into a solution of intermediate 2 (1.83 g ) and triethylamine (1.45 ml) in dry THF (100 ml at 23°, under a nitrogen atmosphere. The mixture was stirred at reflux for 3 h, allowed to cool to 20°, then diluted with ethyl acetate (120 ml) washed with brine (150 ml), dried, and concentrated in vacuo. This material (3.21 g) was crystallised from DCM/CH to give the title compound as a white solid (2.3 g). T.l.c. CH-EA (8:2), Rf 0.34 IR:3393, 3304 (NH) cm-1.

Provenance & Evidence