HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran → HCID 22882010, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | N-[tert-butoxycarbonyl]-L-serine | HCID 98766 | — |
| Catalyst | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22882010 | HCID 22882010 | 92% |
Reaction Steps
7.65 g of N-t-butoxycarbonyl-L-serine and 3.88 g of 3,4-dihydro-2H-pyrane were dissolved in 60 ml of dichloromethane followed by the addition of 0.47 g of pyridinium p-toluene sulfonate and the solution was stirred for 3 hours at room temperature. After the reaction solution was washed with water and saturated brine, the solvent was distilled off under reduced pressure to obtain 9.90 g of the target compound. Yield: 92%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05716958 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-4e467f1f439d4e0c823d07e2238141d9 |
| Source note | uspto-grants-1998_02 |