Ethylenediamine → HCID 19701537, compound

HRID 861937Notes

Reaction equation

HRID 861937 reaction equation
[F:1][C:2]1[CH:11]=[C:10]([N:12]=[C:13]=[S:14])[C:9]([CH3:15])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[CH2:16]([NH2:19])[CH2:17][NH2:18]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([NH:18][CH2:17][CH2:16][NH2:19])=[S:14])[C:9]([CH3:15])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 18465370HCID 18465370, compound

Product 1

HCID 19701537HCID 19701537, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

N-(5-Fluoro-8-methyl-7-quinolinyl/-N'-2-aminoethylthiourea. A solution of 5-fluoro-8-methyl-7-quinolinylisothiocyanate (0.38 g) in toluene (40 mL) is added dropwise to a solution of 1,2-ethylenediamine (0.78 g) in toluene (40 mL). A white precipitate is observed after the reaction stirs for 10 minutes at room temperature. The precipitate is filtered and dried in vacuo to afford N-(5-fluoro-8-methyl-7-quinolinyl)-N'-2-aminoethylthiourea as a white solid.

Workup

  1. filtrationThe precipitate is filtered
  2. customdried in vacuo

Sources & evidence

ORD record
ord-4e1e25fd1086442382ec4eea80eb852e
Source dataset
uspto-grants-1998_02
Patent number
US05716966

Reaction notes

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