Hydrochloric Acid → HCID 19700735, compound

Participants

Reaction Conditions

Reaction Steps

7-(3-Chlorobenzoyl)-furo[3,4-b]pyridin-5-one (4.77 g, 19.4 mmoles) and 0.2N sodium hydroxide (21.4 mmoles) was dissolved in methanol and tetrahydrofuran (100 ml, 1:1). The mixture was heated to 75° C. and stirred for 3 hours and cooled. 1N Hydrochloric acid (20 ml) and water (200 ml) was added to the mixture. The resulting solution was extracted with ethyl acetate and dried over Na2SO4. The solution was filtered and the solvent removed yielding 4.94 g (96.8%) of 2-(hydroxymethyl-3-chlorophenyl)-3-carboxypyridine.

Provenance & Evidence