Hydrochloric Acid → HCID 19700733, compound

Participants

Reaction Steps

To a suspension of 8-(3-chlorophenyl)pyrido[2,3-d]pyridazin-5-one (0.32 g, 1.24 mmoles) in tetrahydrofuran (50 ml) was added sodium hydride (0.06 g, 1.4 mmoles). The mixture was stirred for 1 hour at room temperature. Iodoethane (0.48 g, 3.1 mmoles) was added and the solution was refluxed for 18 hours under an inert atmosphere. The mixture was cooled and acidified by the addition of 50 ml of 1N HCl. The desired compound was isolated by extraction with ethyl acetate (extracted until no product detected in aqueous layer), washed with sodium bicarbonate, brine and dried over magnesium sulfate. The solution was filtered and the solvent removed yielding 0.85 g of the crude desired product. The product was purified by recrystallization from methanol to yield 0.24 g of 6-ethyl-8-(3-chlorophenyl)pyrido-[2,3-d]pyridazin-5-one (67.8%), mp. 117°-118° C.

Provenance & Evidence