Hydrochloric Acid → HCID 19700860, compound

Participants

Reaction Steps

To a suspension of 8- (3-chlorophenyl)pyrido [2,3 -d]pyridazin-5-one (0.33 g, 1.28 mmoles) in tetrahydrofuran (50 ml) was added sodium hydride (0.07 g, 1.53 mmoles). The mixture was stirred at room temperature for 30 minutes under an inert atmosphere. 2-Iodopropane (0.64 ml, 6.4 mmoles) was added and the mixture refluxed for 48 hours. The mixture was cooled and acidified by the addition of 50 ml of 1N HCl. The mixture was extracted with ethyl acetate (3×50 ml) and dried over magnesium sulfate. The solution was filtered and the solvent removed to yield the crude product. The product was purified by crystallization (ethyl ether/hexane) yielding 0.15 g of 6-(2-propyl)-8-(3-chlorophenyl)pyrido[2,3-d]pyridazin-5-one (39%), mp 80°-81° C.

Provenance & Evidence