Triphenylphosphine → HCID 19700962, compound

Participants

Reaction Steps

To a suspension of 8-(3-chlorophenyl) pyrido[2,3-d]pyridazin-5-one (0.21 g, 0.82 mmoles) in tetrahydrofuran (25 ml) was added 3-thiophenemethanol (0.085 ml, 0.9 moles) and triphenyl phosphine (0.32 g, 1.22 moles). To this mixture was added a solution of diisopropyl azodicarboxylate (0.24 ml, 1.22 moles) in tetrahydrofuran (5 ml) in a dropwise manner. The solution was stirred for 3 hours at room temperature. The solvent was removed and the residue chromatographed from hot methanol, yielding 0.15 g of 6-(3-thienylmethyl)-8-(3-chlorophenyl) pyrido[2,3-d]pyridazin-5-one, mp 165°-166° C.

Provenance & Evidence