Triphenylphosphine → HCID 19700655, compound

Participants

Reaction Steps

To a suspension of 8-(3-chlorophenyl)pyrido-[2,3-d]pyridazin-5-one (0.515 g, 2.0 moles), 6-methoxy-3-hydroxymethyl pyridine (0,306g, 2.2 moles) and triphenylphosphine (0.792 g, 3.0 moles) in THF (50 mL) was added diisopropylazodicarboxylate (0.6mL, 3.0 moles). The reaction mixture was stirred for 18 hours at room temperature. The solvent was removed and the product was purified by chromatography (ethyl acetate/hexane 2:3) and crystallized from methanol to yield 0.588g of 8-(3-chlorophenyl)-6-(6-methoxy-3-pyridylmethyl)pyrido[2,3-d]-pyridazin-5-one, mp 145° C.

Provenance & Evidence