HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → Diethyl [(6-amino-3-chloro-2-pyridinyl)methyl]phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Diethyl [[3-chloro-6-(1,3-dihydro-1,3-dioxo-2Hisoindol-2-yl)-2-pyridinyl]methyl]phosphonate | HCID 131720462 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Diethyl [(6-amino-3-chloro-2-pyridinyl)methyl]phosphonate | HCID 86752043 | — |
Reaction Steps
Following the procedure from Example 16, the product from Example 27 (1.0 g, 2.4 mmol) was reacted with hydrazine monohydrate (0.121 g, 2.4 mmol) in CH2Cl2 (25 mL). Workup produced the crude title product which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05716964 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-1a8aca07cf36418c929108cb02a5ad2d |
| Source note | uspto-grants-1998_02 |