HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromopyruvate → Ethyl 6-chloro-5-[(diethoxyphosphinyl)methyl]imidazo[1,2-a]pyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | Diethyl [(6-amino-3-chloro-2-pyridinyl)methyl]phosphonate | HCID 86752043 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | Ethyl 6-chloro-5-[(diethoxyphosphinyl)methyl]imidazo[1,2-a]pyridine-2-carboxylate | HCID 19701397 | 13% |
Reaction Steps
Following the procedure for Example 17, the residue from Example 28 was combined with ethyl bromopyruvate (0.468 g, 2.4 mmol) in DME (25 mL). After the resulting salt was refluxed in abs EtOH (30 mL) for 6 h, workup and puricication produced 0./114 g (13% of title compound).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05716964 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-277790dcd3c24a0ba46626ad1f117d97 |
| Source note | uspto-grants-1998_02 |