HCID 19701381, compound → 6-Chloro-5-(phosphonomethyl)imidazo[1,2-a]pyridine-2-carboxylic acid

HRID 861993Notes

Reaction equation

HRID 861993 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:17]=[C:18]([C:20]([O:22]CC)=[O:21])[N:19]=2)[C:7]=1[CH2:8][P:9]([O:14]CC)([O:11]CC)=[O:10].[P:25]([CH2:29][C:30]1[C:31]2[N:32]([CH:36]=[C:37]([C:39]([OH:41])=[O:40])[N:38]=2)[CH:33]=[CH:34][CH:35]=1)([OH:28])([OH:27])=[O:26]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:17]=[C:18]([C:20]([OH:22])=[O:21])[N:19]=2)[C:7]=1[CH2:8][P:9]([OH:11])([OH:14])=[O:10].[P:25]([CH2:29][C:30]1[C:31]2[N:32]([CH:36]=[C:37]([C:39]([OH:41])=[O:40])[N:38]=2)[CH:33]=[CH:34][CH:35]=1)([OH:27])([OH:28])=[O:26]

Participants

4

Reactant 2

HCID 19701381HCID 19701381, compoundHCID 19701397Ethyl 6-chloro-5-[(diethoxyphosphinyl)methyl]imidazo[1,2-a]pyridine-2-carboxylate

Product 2

HCID 197011086-Chloro-5-(phosphonomethyl)imidazo[1,2-a]pyridine-2-carboxylic acidHCID 19701381HCID 19701381, compound

Procedure

Following the procedure in Example 7, the product from Example 29 was refluxed in 4N. HCl (7 mL) for 7 h. Workup produced the title product HCl salt.

Sources & evidence

ORD record
ord-81dbc933f9ca454fa3baed1847619145
Source dataset
uspto-grants-1998_02
Patent number
US05716964

Reaction notes

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