HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 861997Generated: October 28, 2026
Diisopropylethylamine → Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylate
https://huagongshe.com/reaction/861997
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Diethylphosphite | HCID 3780918 | — |
| Reactant | Ethyl 5-formylimidazo[1,2-a]pyridine-2-carboxylate | HCID 19701256 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylate | HCID 15233873 | 66% |
Reaction Steps
Diethyl phosphite (1.7 g, 12.3 mmol, Aldrich), N,N-diisopropylethylamine (1.63 g, 12.4 mmol, Aldrich) and toluene (60 mL) were combined in a 100 mL flask equipped with a N2 inlet and condensor. After warming this solution to 60° C., the product from Example 54 was added. After stirring at 75°-80° C. for 3 h, all solvent was removed from this mixture and the residue was chromatographed (7.5/92.4/0.1 isopropanol/CH2Cl2 /HOAc) to give 1.2 g (66%) of the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05716964 |
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| Source dataset | uspto-grants-1998_02 |
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| ORD ID | ord-53c716aaa28b41adac3665b2d0444bf6 |
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| Source note | uspto-grants-1998_02 |
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