Ethyl 3-chloro-3-oxopropionate → HCID 19701231, compound

HRID 862000Notes

Reaction equation

HRID 862000 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][CH:3]=1.Cl[C:11]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=O>O1CCOCC1>[OH:9][CH2:8][C:6]1[N:7]2[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:11][N:1]=[C:2]2[CH:3]=[CH:4][CH:5]=1

Participants

4

Reactant 2

HCID 118931Ethyl 3-chloro-3-oxopropionateHCID 111826066-Amino-2-pyridinemethanol

Product 1

HCID 19701231HCID 19701231, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title product is prepared by the reaction of the title compound from Example 3 with ethyl a-chloroformylacetate by the method of Example 4 or in dioxane by the procedure of W. W. Paudley; R. A. VanDahm; Y. N. Park, J. Heterocyclic Chem., 1972, (9), 81-85.

Sources & evidence

ORD record
ord-d5d06f99deb842738a95a12a93125f41
Source dataset
uspto-grants-1998_02
Patent number
US05716964

Reaction notes

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