Hydrochloric Acid → HCID 19701612, compound

Participants

Reaction Steps

A mixture of 2-(5-chloro-2-methoxymethoxybenzoyl)-3-(1,3-dioxolan-2-yl)pyridine (3.41 g), hydrochloric acid (5.0 ml) and THF (35 ml) was stirred for 27 hours at room temperature. The reaction mixture was neutralized with an aqueous solution of sodium hydroxide, followed by extraction with ethyl acetate. The extract solution was washed with a saturated aqueous saline solution, then the solvent was distilled off to leave 2-(5-chloro-2-hydroxybenzoyl)-3-formylpyridine (2.03 g) (Compound E-10). The physical properties and spectrum data are shown in Table 16 and Table 18.

Provenance & Evidence