Hydrochloric Acid → HCID 19701583, compound

Participants

Reaction Steps

A mixture of 2-(5-chloro-2-methoxymethoxybenzoyl)-3-cyanopyridine (1.50 g), hydrochloric acid (2.5 ml) and THF (17.5 ml) was stirred for 13 hours at room temperature. The reaction mixture was neutralized with an aqueous solution of sodium hydroxide, followed by extraction with ethyl acetate. The extract solution was washed with a saturated aqueous saline solution and dried (anhydrous sodium sulfate), which was purified by means of a silica gel column chromatography (eluent: ethyl acetate/hexane) to give 2-(5-chloro-2-hydroxybenzoyl)-3-cyanopyridine (1.10 g) (Compound E-13). The physical properties and spectrum data are shown in Table 16 and Table 19.

Provenance & Evidence