Dimethylamine → HCID 19701623, compound

Participants

Reaction Steps

A mixture of 2-(5-chloro-4-fluoro-2-methoxymethoxybenzoyl)-3-methoxymethoxypyridine (1.98 g), a 50% aqueous solution of dimethylamine (20 ml) and DMF (50 ml) was stirred overnight at room temperature. The reaction mixture was subjected to extraction with ethyl acetate. The organic layer was washed with water and a saturated aqueous saline solution, successively, which was then dried (anhydrous magnesium sulfate). The solvent was distilled off, and the residue was purified by means of a silica gel column chromatography (ethyl acetate/hexane) to afford 2-(5-chloro-4-dimethylamino-2-methoxymethoxybenzoyl)-3-methoxymethoxypyridine (1.82 g) (Compound F-3).

Provenance & Evidence