HCID 53951647, compound → HCID 19701580, compound

Participants

Reaction Steps

To a solution of 5-cyano-4-fluoro-2-methoxymethoxybenzyl alcohol (10.0 g) in dichloromethane (500 ml) was added activated manganese dioxide (31.4 g). The mixture was stirred overnight at room temperature, and filtered through celite to remove manganese dioxide. The filtrate was condensed under reduced pressure to give a solid, which was washed with hexane to yield 5-cyano-4-fluoro-2-methoxymethoxybenzaldehyde (8.01 g) (Compound B-50). The physical properties was shown in Table 8.

Provenance & Evidence