Water → HCID 136463847, compound

Participants

Reaction Steps

Pyridine (0.30 ml) was dissolved in chloroform (10 ml). To the solution was added acetic anhydride (0.18 ml), and the mixture was stirred for 50 minutes. To the reaction mixture was then added (Z)-2-(2-hydroxy-5-trifluoromethylbenzoyl)-3-hydroxypyridine O-t-butyloxime (0.21 g), and the mixture was stirred for 3 hours at room temperature. To the reaction mixture were added water and chloroform for extraction. The organic layer was dried (anhydrous magnesium sulfate), followed by distilling off the solvent under reduced pressure. The residue was purified by means of a silica gel column chromatography (eluted with ethyl acetate/hexane, then with ethyl acetate/THF) to give (Z)-3-acetoxy-2-(2-hydroxy-5-trifluoromethylbenzoyl)pyridine O-t-butyloxime (0.20 g) (Compound 46).

Provenance & Evidence