Hydrogen Peroxide → HCID 136463822, compound

Participants

Reaction Steps

To a solution of (Z)-2-(5-cyano-2-hydroxybenzoyl)-3-hydroxypyridine O-t-butyloxime (0.98 g) in ethanol (20 ml) were added at 0° C. 6N NaOH (0.15 ml) and 30% aqueous solution of hydrogen peroxide (1.5 ml). The mixture was stirred for 2 hours at temperatures ranging from 50° to 60° C. The reaction mixture was cooled by aeration, which was then neutralized with a saturated aqueous solution of potassium hydrogensulfate, then the solvent was concentrated. The concentrate was subjected to extraction with chloroform and dried (anhydrous magnesium sulfate), followed by distilling off the solvent. The residue was recrystallized from chloroform to give (Z)-2-(5-carbamoyl-2-hydroxybenzoyl)-3-hydroxypyridine O-t-butyloxime (0.42 g) (Compound 71).

Provenance & Evidence