Potassium Carbonate → HCID 136463821, compound

Participants

Reaction Steps

In methanol (50 ml) was dissolved 2-[2-hydroxy-5-(2-trimethylsilylethynyl)benzoyl]-3-hydroxypyridine O-t-butyl oxime (0.70 g). To the solution was added potassium carbonate (0.1 g) at room temperature, followed by heating for 3 hours under reflux. The reaction mixture was cooled by aeration, then the solvent was distilled off. To the residue were added chloroform and water for extraction. The organic layer was dried (anhydrous magnesium sulfate), then the solvent was distilled off under reduced pressure. The residue was purified by means of a silica gel column chromatography (eluted with ethyl acetate/hexane) to give (Z)-2-(5-ethynyl-2-hydroxybenzoyl)-3-hydroxypyridine O-t-butyloxime (0.21 g) (Compound 115).

Provenance & Evidence