Diethyl Ether → HCID 178454586, compound

Participants

Reaction Steps

To a solution of (Z)-2-(5-bromo-2-hydroxybenzoyl)-3-formylpyridine O-t-butyloxime (500 mg) in acetone (4 ml) was added, at room temperature, Jones reagent (1 ml), and the mixture was stirred for 30 minutes. To the reaction mixture was added diethyl ether. Insolubles then formed were filtered off. To the filtrate was added a small volume of isopropyl alcohol, and the mixture was concentrated. The concentrate was purified by means of a silica gel column chromatography (eluent: diethyl ether) to give (Z)-2-(5-bromo-2-hydroxybenzoyl)nicotinic acid O-t-butyloxime (240 mg (Compound 138).

Provenance & Evidence