Sodium Sulfite → HCID 136463710, compound

Participants

Reaction Steps

A solution of (Z)-2-(5-bromo-2-hydroxybenzoyl)-3-cyanopyridine O-t-butyloxime (350 mg) and 50% m-chloroperbenzoic acid (710 mg) in chloroform (5 ml) was stirred for 6 hours at 50° C. The reaction mixture was cooled by aeration, which was poured into an aqueous solution of sodium sulfite. The mixture was stirred and subjected to extraction with chloroform. The extract solution was washed successively with a saturated aqueous solution of sodium hydrogencarbonate and a saturated aqueous saline solution, dried (anhydrous sodium sulfate), and concentrated. The concentrate was purified by means of a silica gel column chromatography (eluent: ethyl acetate/hexane) to give (Z)-2-(5-bromo-2-hydroxybenzoyl)-3-cyanopyridine N-oxide O-t-butyloxime (120 mg) (Compound 145).

Provenance & Evidence