HRID862175

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(Nc1ccc(Cc2nc(Cc3ccccc3)no2)cc1Br)C(F)(F)F

HCID19702140

未命名化合物

HCID54485243

(R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene

C15H19NO3

PRODUCTS

生成物

结构：O=C(OCc1ccccc1)N1CCC[C@@H]1C=CCN(C(=O)C(F)(F)F)c1ccc(Cc2nc(Cc3ccccc3)no2)cc1Br

HCID54350671

未命名化合物

收率 90%

PROCEDURE

实验过程

4-(3-Benzyl-1,2,4-oxadiazol-5-ylmethyl)-2-bromo-1-trifluoroacetylaminobenzene and (R)-1-(N-benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene were used. Chromatography using elution with 5% either in methylene chloride afforded the title compound (90%) as a thick yellow oil: Rf =0.75 (CHCl3 --CH3OH 20:1); LRMS (m/z, relative intensity) 683 (M+,18).

WORKUP

后处理

washelution with 5%

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-03e95b20f0e24067a3272dcfd2cfebf8
来源数据集: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05717102
来源说明: uspto-grants-1998_02

反应 SMILES

[CH2:1]([C:8]1[N:12]=[C:11]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:26])[C:22]([F:25])([F:24])[F:23])=[C:16]([Br:27])[CH:15]=2)[O:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:28]([O:35][C:36]([N:38]1[CH2:42][CH2:41][CH2:40][C@@H:39]1[CH:43]=[CH:44][CH2:45]O)=[O:37])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH2:28]([O:35][C:36]([N:38]1[CH2:42][CH2:41][CH2:40][C@@H:39]1[CH:43]=[CH:44][CH2:45][N:20]([C:17]1[CH:18]=[CH:19][C:14]([CH2:13][C:11]2[O:10][N:9]=[C:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[N:12]=2)=[CH:15][C:16]=1[Br:27])[C:21](=[O:26])[C:22]([F:25])([F:23])[F:24])=[O:37])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1