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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 862282Generated: October 25, 2026

2-(3,4-Dimethoxyphenyl)propan-2-amine → N-[1-(3,4-Dimethoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamide

https://huagongshe.com/reaction/862282

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3,4-Dimethoxyphenyl)propan-2-amineHCID 3032233—
ReactantS-2pyridyl 3-cyanoandrosta-3,5-diene-17beta-thiocarboxylateHCID 15380265—
ProductN-[1-(3,4-Dimethoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamideHCID 5705157060%

Reaction Steps

Following a procedure similar to that described in Example 3(b), but using S-2-pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 1-(3,4-dimethoxyphenyl)-1-methylethylamine (prepared as described in Preparation 10e) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 60%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05717088
Source datasetuspto-grants-1998_02
ORD IDord-f814497772a4410b91fcbac7304e3e66
Source noteuspto-grants-1998_02