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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 862284Generated: October 25, 2026

2-(3-Methoxyphenyl)-2-propanamine → N-[1-(3-Methoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamide

https://huagongshe.com/reaction/862284

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-Methoxyphenyl)-2-propanamineHCID 13911310—
ReactantS-2pyridyl 3-cyanoandrosta-3,5-diene-17beta-thiocarboxylateHCID 15380265—
ProductN-[1-(3-Methoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamideHCID 6764684164%

Reaction Steps

Following a procedure similar to that described in Example 3(b), but using S-2-pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 1-(3-methoxyphenyl)-1-methylethylamine (prepared as described in Preparation 10b) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 64%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05717088
Source datasetuspto-grants-1998_02
ORD IDord-557e9c1ae0394fb9a640d08505ac07a5
Source noteuspto-grants-1998_02