反应详情

A solution containing 17.5 g of methyl 2-methyl-2-(2-thienyl)propionate [prepared as described in step (i) above], 12.6 g of potassium hydroxide, 72 ml of water, and 168 ml of 1,4-dioxane was heated under reflux for 2 hours. At the end of this time, it was diluted with ice-water, and extracted twice with diethyl ether. The aqueous layer was adjusted to a weakly acidic pH, extracted three times with diethyl ether, washed with water and with a saturated aqueous solution of sodium chloride, in that order, dried over anhydrous magnesium sulfate, and concentrated by evaporation under reduced pressure to give 15.8 g of the title compound.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. extractionextracted twice with diethyl ether
4. extractionextracted three times with diethyl ether
5. washwashed with water and with a saturated aqueous solution of sodium chloride, in that order
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated by evaporation under reduced pressure