Methanesulfonyl chloride → HCID 54281668, compound

Participants

Reaction Steps

To a stirred solution of 3-(4-aminobenzylidene)-7-azaoxindol (2.373 g, 10 mmol) in pyridine (10 ml) was added gradually mesylchloride (1.146 g, 10 mmol) at 0°-5° C. under cooling. The reaction mixture was stirred for about 5 h at 0°-5° C. and then for 15 h at room temperature. The mixture was poured onto an ice-water mixture, the precipitate filtered off, the residue washed thoroughly with water and then chromatographed on silica gel using CHC3 -MeOH mixtures as eluant. Thus pure title compound was obtained in about 70% yield.

Provenance & Evidence