HCID 86752081, compound → HCID 86752080, compound

Participants

Reaction Steps

To a solution of 4-methoxybenzyl (7R,8S)-5-acetoxy-8-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-9-oxo-1-azabicyclo[5.2.0]non-2,4-diene-2-carboxylate (88 mg, 0.17 mM) in methanol (6 ml) was added hydrochloric acid (10 drops, 2N). After 6 hours the solvent was evaporated and the product purified by chromatography on silica (10 ml), eluting with ethyl acetate/dichloromethane, (1:1) to give 4-methoxybenzyl (7R,8S)-5-acetoxy-8-[(1R)-1-hydroxyethyl]-9-oxo-1-azabicyclo[5.2.0]non-2,4-diene-2-carboxylate (29 mg, 39%).

Provenance & Evidence