Formic Acid → HCID 374038, compound

HRID 862415Notes

Reaction equation

HRID 862415 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH2:7])=[O:6].[CH:11](O)=[O:12]>>[CH:11]([NH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH2:7])=[O:6])=[O:12]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 16453-Aminobenzamide

Product 1

HCID 374038HCID 374038, compoundYield 68%

Procedure

10 gm of 3-aminobenzamide and 80 ml of 98 to 100% formic acid were refluxed for 60 minutes. The formic acid was removed by evaporation under vacuum; the residual oily product was mixed with water and evaporated to yield a solid residue. This solid was crystallized from water to give 8.2 gm (yield=68%) of white, round crystals with a melting point of 176° C. to 177° C. Mass spectrum analysis indicated a molecular weight of 164.

Workup

  1. customThe formic acid was removed by evaporation under vacuum
  2. additionthe residual oily product was mixed with water
  3. customevaporated
  4. customto yield a solid residue
  5. customThis solid was crystallized from water
  6. customto give 8.2 gm (yield=68%) of white, round crystals with a melting point of 176° C. to 177° C

Sources & evidence

ORD record
ord-1be7489bc63247839213277e30cc0383
Source dataset
uspto-grants-1998_02
Patent number
US05719151

Reaction notes

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