Sodium Hydroxide → HCID 70076641, compound

HRID 862427Notes

Reaction equation

HRID 862427 reaction equation
[ClH:1].[O:2]1[CH2:7][CH2:6][N:5]([N:8]=[CH:9][C:10]2[CH:34]=[CH:33][C:13]([C:14]([NH:16][C:17]3[CH:26]=[C:25]4[C:20]([CH2:21][CH2:22][CH:23]([CH2:27][C:28]([O:30]CC)=[O:29])[CH2:24]4)=[CH:19][CH:18]=3)=[O:15])=[CH:12][CH:11]=2)[CH2:4][CH2:3]1.[OH-].[Na+]>C(O)C>[ClH:1].[O:2]1[CH2:7][CH2:6][N:5]([N:8]=[CH:9][C:10]2[CH:11]=[CH:12][C:13]([C:14]([NH:16][C:17]3[CH:26]=[C:25]4[C:20]([CH2:21][CH2:22][CH:23]([CH2:27][C:28]([OH:30])=[O:29])[CH2:24]4)=[CH:19][CH:18]=3)=[O:15])=[CH:33][CH:34]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70076057HCID 70076057, compound

Product 1

HCID 70076641HCID 70076641, compoundYield 63.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound (0.15 g) obtained in Example 1 was suspended in ethanol (10 ml), a 1N aqueous sodium hydroxide solution (1.5 ml) was added, and the mixture was stirred overnight. The solvent was distilled off under reduced pressure, a 3N aqueous hydrochloric acid solution was added, and the formed precipitate was filtered, washed with water, and dried under reduced pressure to obtain the entitled compound (0.09 g).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. additiona 3N aqueous hydrochloric acid solution was added
  3. filtrationthe formed precipitate was filtered
  4. washwashed with water
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-f0d1e83f03a3478fa3ccb1be3df8cd4b
Source dataset
uspto-grants-1998_02
Patent number
US05719145

Reaction notes

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