Thionyl Chloride → HCID 70077572, compound

HRID 862428Notes

Reaction equation

HRID 862428 reaction equation
S(Cl)([Cl:3])=O.[CH3:5][O:6][CH:7](O)[CH3:8].Cl.[O:11]1[CH2:16][CH2:15][N:14]([N:17]=[CH:18][C:19]2[CH:41]=[CH:40][C:22]([C:23]([NH:25][C:26]3[CH:27]=[C:28]4[C:33](=[CH:34][CH:35]=3)[O:32][CH2:31][CH:30]([CH2:36][C:37]([OH:39])=[O:38])[CH2:29]4)=[O:24])=[CH:21][CH:20]=2)[CH2:13][CH2:12]1>>[ClH:3].[O:11]1[CH2:16][CH2:15][N:14]([N:17]=[CH:18][C:19]2[CH:20]=[CH:21][C:22]([C:23]([NH:25][C:26]3[CH:27]=[C:28]4[C:33](=[CH:34][CH:35]=3)[O:32][CH2:31][CH:30]([CH2:36][C:37]([O:39][CH2:8][CH2:7][O:6][CH3:5])=[O:38])[CH2:29]4)=[O:24])=[CH:40][CH:41]=2)[CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 24386Thionyl ChlorideHCID 30156371-MethoxyethanolHCID 70076446HCID 70076446, compound

Product 1

HCID 70077572HCID 70077572, compound

Procedure

Thionyl chloride (0.4 ml) was dropwise added to methoxyethanol (5 ml) with ice cooling and stirred for 10 minutes at the intact temperature. To the resulting solution the compound (0.2 g) obtained in Example 5 was added and stirred overnight at room temperature. The solvent was distilled off under reduced pressure and the concentrated residue was washed with ethyl ether to obtain the entitled compound (0.12 g).

Workup

  1. stirringstirred overnight at room temperature
  2. distillationThe solvent was distilled off under reduced pressure
  3. washthe concentrated residue was washed with ethyl ether

Sources & evidence

ORD record
ord-1d9268399165408e975c9963d8293d35
Source dataset
uspto-grants-1998_02
Patent number
US05719145

Reaction notes

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