Sulfuric Acid → HCID 70075384, compound

Participants

Reaction Conditions

Reaction Steps

The compound (0.2 g) obtained in Example 5, was suspended in n-butanol. Concentrated sulfuric acid (0.1 ml) was dropwise added to the suspension and heated at 100° C. for an hour. The solvent was distilled off under reduced pressure and the concentrated residue was purified by reversed C18 column chromatography using a mixture, water:acetonitrile:trifluoroacetic acid=30:70:0.1, as a developer. The desired fraction was concentrated under reduced pressure. The concentrated residue was treated with a hydrochloric acid/dioxane solution to obtain the entitled compound (0.16 g).

Provenance & Evidence