HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[2-(1-Oxo-7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)-acetylamino]-propionic acid → (S)-3-[2-(1-Oxo-7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)-acetylamino]-3-pyridin-3-yl-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[2-(1-Oxo-7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)-acetylamino]-propionic acid | HCID 10689869 | — |
| Reactant | Ethyl (3S)-3-amino-3-(pyridin-3-yl)propanoate--hydrogen chloride (1/2) | HCID 44891224 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-3-[2-(1-Oxo-7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)-acetylamino]-3-pyridin-3-yl-propionic acid | HCID 10789118 | — |
Reaction Steps
Following the procedure described for 1-7, but substituting β-alanine ethyl ester hydrochloride (Aldrich) for ethyl 3-amino-3(S)-(3-pyridyl)propionate dihydrochloride, the title compound was prepared. Rf (silica, EtOAc)=0.3. ##STR37## N-{[7-(Piperazin-1-yl)-3,4-dihydro-1(1H)-isoquinolinone-2-yl]acetyl}-β-alanine (1-14)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05719144 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-3dd3a8570a6944259370c95b40054850 |
| Source note | uspto-grants-1998_02 |