Acetic Acid → HCID 178520291, compound

HRID 862468Notes

Reaction equation

HRID 862468 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:32])[CH2:25][C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH2:20][CH2:19]3)[C:9]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:10]=3[CH2:11][CH2:12][C:3]=12.C(O)(=O)C.[Br:37]Br.C(O)(=O)C>O>[Br:37][C:7]1[C:2]([OH:1])=[C:3]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:9]=3[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:32])[CH2:25][C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH2:20][CH2:19]3)[C:4]2=[N:5][CH:6]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 87433071bromine AcOHHCID 178520292HCID 178520292, compound

Product 1

HCID 178520291HCID 178520291, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of the title compound from Example 252 (0.19 grams) and glacial acetic acid (4 mL) was added a 0.7M bromine-acetic acid solution (0.7 mL) at 25° C. under N2. After 10 minutes, water was added and the resulting solid was filtered and washed with water several times and dried to give the title compound (0.18 grams, 71%, MH+ 526).

Workup

  1. filtrationthe resulting solid was filtered
  2. washwashed with water several times
  3. customdried

Sources & evidence

ORD record
ord-f39740bbe01e4c5f98fcdb4840bf344b
Source dataset
uspto-grants-1998_02
Patent number
US05719148

Reaction notes

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