Acetic Acid → HCID 178522205, compound

HRID 862471Notes

Reaction equation

HRID 862471 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24]([NH:26][C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)=[O:25])[CH2:20][CH2:19]3)[C:9]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:10]=3[CH2:11][CH2:12][C:3]=12.C(O)(=O)C.[Br:37]Br.C(O)(=O)C>O>[Br:37][C:7]1[C:2]([OH:1])=[C:3]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:9]=3[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24]([NH:26][C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)=[O:25])[CH2:20][CH2:19]3)[C:4]2=[N:5][CH:6]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 87433071bromine AcOHHCID 178522206HCID 178522206, compound

Product 1

HCID 178522205HCID 178522205, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of the title compound from Example 263 (0.34 grams) and glacial acetic acid (10 mL) was added a 0.7M bromine-acetic acid solution (4 mL) at 25° C. under N2. After 10 minutes, water was added and the resulting solid was filtered and washed with water several times and dried to give the title compound (Yield 0.31 grams, 67%, MH+ 527).

Workup

  1. filtrationthe resulting solid was filtered
  2. washwashed with water several times
  3. customdried

Sources & evidence

ORD record
ord-d2c3fd44db5a473aa1874b1f0a3e195b
Source dataset
uspto-grants-1998_02
Patent number
US05719148

Reaction notes

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