HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → Chromanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | alpha-Hydroxyacetophenone | HCID 68490 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | Chromanone | HCID 68110 | — |
Reaction Steps
2-Hydroxyacetophenon (compound 1, R1 is as defined above) and compound 2 wherein R2 and R3 are as defined above are refluxed under heating in a solvent such as benzene, chlorobenzene, toluene and xylene, in the presence of a secondary amine such as pyrrolidine, piperidine and morpholine, using a Dean-Stark apparatus, while removing liberated water to give 4-chromanon (compound 3 wherein R1, R2 and R3 are as defined above).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05719155 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-8a00874fe6d646749b84b530369c63ff |
| Source note | uspto-grants-1998_02 |