反应详情

4-Pyrazolecarboxylic acid (514 mg) was dissolved in methanol (10 ml) and sulfuric acid (0.25 ml), and the mixture was stirred at room temperature for 2 hours, followed by refluxing under heating for 4 hours. After cooling, a 28% solution (0.95 ml) of sodium methylate in methanol was added to the reaction mixture for neutralization and the solvent was distilled away. Chloroform was added to the residue, and the residue was washed with water and brine and dried over anhydrous magnesium sulfate. The solvent was distilled away to give 433 mg of the title compound.

1. temperatureby refluxing
2. temperatureunder heating for 4 hours
3. temperatureAfter cooling
4. distillationthe solvent was distilled away
5. additionChloroform was added to the residue
6. washthe residue was washed with water and brine
7. dry with materialdried over anhydrous magnesium sulfate
8. distillationThe solvent was distilled away