m-Chloroperbenzoic acid → HCID 10837757, compound

Participants

Reaction Steps

(-)-(3S,4R)-6-Cyano-3,4-dihydro-4-[(1,6-dihydro-1-(2-methylthioethyl)-6-oxo-3-pyridazinyl)amino]-2,2-bis(methoxymethyl)-2H-1-benzopyran-3-ol (262 mg) obtained in Example 57 was dissolved in dichloromethane (20 ml), and m-chloroperbenzoic acid (152 mg) was added under ice-cooling. The mixture was reacted for 30 minutes. The reaction mixture was poured in a saturated aqueous solution of sodium hydrogen carbonate and extracted with chloroform. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was distilled away under reduced pressure to give a residue. The residue was purified by silica gel column chromatography (chloroform:methanol=30:1-20:1) to give 182 mg (65%) and 89 mg (33%) of the title compounds, respectively.

Provenance & Evidence