Ethanol hydrochloride → 1-(Benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride

HRID 862544Notes

Reaction equation

HRID 862544 reaction equation
[ClH:1].C(O)C.[S:5]1[CH:9]=[CH:8][C:7]2[CH:10]=[C:11]([CH:14]([OH:28])[CH2:15][O:16][CH2:17][CH:18]3[CH2:23][N:22](C=O)[CH2:21][CH2:20][N:19]3C=O)[CH:12]=[CH:13][C:6]1=2>CO>[ClH:1].[ClH:1].[S:5]1[CH:9]=[CH:8][C:7]2[CH:10]=[C:11]([CH:14]([OH:28])[CH2:15][O:16][CH2:17][CH:18]3[CH2:23][NH:22][CH2:21][CH2:20][NH:19]3)[CH:12]=[CH:13][C:6]1=2

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 53826975(Benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol

Product 1

HCID 675982851-(Benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 1.5 ml of methanol was dissolved 270 mg of -(benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol. To the solution was added 1.5. ml. of a 5N dry hydrogen chloride-ethanol solution. The resulting mixture was allowed to stand at room temperature overnight. The resulting crystals were collected by filtration, washed with ethanol, and dried to obtain 150 mg of 1-(benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride (compound No. 355).

Workup

  1. additionTo the solution was added 1.5
  2. filtrationThe resulting crystals were collected by filtration
  3. washwashed with ethanol
  4. customdried

Sources & evidence

ORD record
ord-8ed52643e5b446e7bd980fc348aed61e
Source dataset
uspto-grants-1998_02
Patent number
US05719150

Reaction notes

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