Methanol → HCID 131720475, compound

Participants

Reaction Steps

A solution of (S)-9-bromo-5-[p-tert-butoxycarbonylaminomethyl-o-(methoxycarbonyl)phenylcarbamoylmethyl]-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione (680 mg, 1.06 mmol) in a mixture of 1N sodium hydroxide (6 mL), THF (6 mL), and methanol (6 mL) was stirred for 3.5 h at room temperature and the solvent was concentrated to ca. 6 mL. To the residue was added 5% potassium hydrogen sulfate and extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate, and concentrated to give 608 mg of the title compound.

Provenance & Evidence