HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 5-(5-tert-butoxycarbonylaminomethyl-2-nitrophenyl)pent-4-enoate → 2-(4-Ethoxycarbonylbutyl)-4-tert-butoxycarbonylaminomethylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 5-(5-tert-butoxycarbonylaminomethyl-2-nitrophenyl)pent-4-enoate | HCID 53964031 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(4-Ethoxycarbonylbutyl)-4-tert-butoxycarbonylaminomethylaniline | HCID 19698362 | 108% |
Reaction Steps
A solution of ethyl 5-(5-tert-butoxycarbonylaminomethyl-2-nitrophenyl)pent-4-enoate (560 mg, 1.48 mmol) in ethyl acetate (20 mL) was hydrogenated over platinum oxide (100 mg) under atmospheric pressure of hydrogen at room temperature for 2.5 h. The mixture was passed through celite and the filtrate was concentrated to give 560 mg of the title compound (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05719152 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-22ab9fbb19a6431c959843ea78f7af95 |
| Source note | uspto-grants-1998_02 |