HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-(5-tert-butoxycarbonylaminomethyl-2-nitrophenyl)-2-ethoxycarbonylbutanoate → 2-(3,3-Diethoxycarbonylpropyl)-4-tert-butoxycarbonylaminomethylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-(5-tert-butoxycarbonylaminomethyl-2-nitrophenyl)-2-ethoxycarbonylbutanoate | HCID 19698384 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(3,3-Diethoxycarbonylpropyl)-4-tert-butoxycarbonylaminomethylaniline | HCID 19698356 | 94% |
Reaction Steps
A solution of ethyl 4-(5-tert-butoxycarbonylaminomethyl-2-nitrophenyl)-2-ethoxycarbonylbutanoate (3.2 g, 7.3 mmol) in ethyl acetate (30 mL) was hydrogenated over palladium/charcoal (500 mg) under atmospheric pressure of hydrogen at room temperature for 2.5 h. The mixture was passed through celite and the filtrate was concentrated to give 2.8 g of the title compound (94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05719152 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-f9b375f800ca443185a5967473b355a3 |
| Source note | uspto-grants-1998_02 |