Ammonia → HCID 11949321, compound

HRID 862609Notes

Reaction equation

HRID 862609 reaction equation
C[CH:2]([CH2:6][C:7]1[O:8][C:9]([C:19]2[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=2)=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[N:11]=1)[C:3](O)=[O:4].[NH3:29]>CO>[F:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[N:11]=[C:7]([CH2:6][CH2:2][C:3]([NH2:29])=[O:4])[O:8][C:9]=2[C:19]2[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19698543HCID 19698543, compound

Product 1

HCID 11949321HCID 11949321, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-[4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl]propanamide was prepared by treating methyl 3-[4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl]propanoic acid, (Example 12) with excess ammonia in methanol for 5 days. Melting point: 193°-195° C.

Sources & evidence

ORD record
ord-d283fa609fd143d8b91fd055eff4d0ce
Source dataset
uspto-grants-1998_02
Patent number
US05719163

Reaction notes

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