Hydrochloric Acid → HCID 21851186, compound

Participants

Reaction Steps

Ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-[2-(1-methylimidazol-2-yl)ethyl]quinoline-3-carboxylate (9.0 g) was suspended in ethanol (40 ml), and ethanolic hydrogen chloride (22%, 10 g) was added. After stirring the mixture at room temperature for 5 minutes, ethyl ether (150 ml) was added, and the resulting crystals were collected by filtration and recrystallized from ethanol-ethyl ether to give ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-[2-(1-methylimidazol-2-yl)ethyl]quinoline-3-carboxylate dihydrochloride (9.1 g).

Provenance & Evidence