HCID 22097613, compound → Imidazole-1-butyric acid

HRID 862661Notes

Reaction equation

HRID 862661 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([O:11]CC2C=CC=CC=2)=[O:10])[CH:5]=[CH:4][N:3]=[CH:2]1>[C].[Pd].C(O)C>[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 22097613HCID 22097613, compound

Product 1

HCID 3055390Imidazole-1-butyric acidYield 75%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture of benzyl 4-(1-imidazolyl)butyrate (7.4 g), palladium-carbon (5%)(1.0 g) and ethanol (400 ml) was subjected to catalytic hydrogenation at room temperature and 1 atm. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, and the crystals were recrystallized from ethanol to give 4-(1-imidazolyl)butyric acid (3.4 g, 75%). Colorless prisms. mp. 125°-126° C.

Workup

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customthe crystals were recrystallized from ethanol

Sources & evidence

ORD record
ord-0fb17e1b862243f5973735eedc67bc91
Source dataset
uspto-grants-1998_02
Patent number
US05719157

Reaction notes

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